The full genome sequence and extensive biological characterization of model organisms such as mouse, Drosophila, C. elegans, and yeasts provide powerful tools to understand human biology. We use custom technologies to determine orthologous genes and pathways in multiple genomes, and to integrate functional information from large databases and the literature to the annotation of human biological processes. This has lead to the characterization of dozens of 'novel' human genes and driven experimental design for the validation and invalidation of several drug targets, both novel and partially characterized.
Along with functional annotation, the comparison of homologous sequences can tell a great deal about sequence-structure-function relationships, which we cover in a separate section.
We offer profiling of everything from a single gene and its orthologs, to intensive analysis of large gene families.